Welcome to BMC
The BioMedical Center (BMC) of the University of Iceland, is an official collaboration between research groups working in biomedical molecular life sciences within the University, the University Hospital and Reykjavik University.
In this paper, Stefán Sigurðsson and colleagues studied epigenetic modifications of the BRCA1 gene in breast cancer. BRCA1 was found to be promoter hypermethylated in 3% of breast cancer cases and the methylation status was predictive of improved disease outcome in patients receiving cytotoxic DNA damage-inducing drugs. In JNCI Cancer Spectrum
In this article, Guðrún Valdimarsdottir and colleagues substantiate the importance of BMP9/ALK1 in vascular commitment of hESCs and endothelial sprouting via the secreted extracellular matrix protein EGFL7. They demonstrate the connection of EGFL7 to the NOTCH- and ERK pathway and reveal its role in remodeling of the extracellular matrix using CRISPR/Cas9-mediated deletion of EGFL7. In Stem Cell Reports