Protein Structure and Disorder Prediction uising AlphaFold

Abstract: Accurately describing the structure and disorder of proteins is of central importance in gaining a mechanistic understanding of their function. Traditional techniques for structure prediction have greatly enhanced our understanding of protein function, yet their limitations and resource-intensive nature limits our view to a fraction of the known proteome. The past few decades have seen massive leaps in proteins structure determination from amino acid sequence alone, and the recent publication of AlphaFold 2 represents the first truly accurate protein structure prediction model, resolving protein backbones to atomic accuracy.

In this seminar we will explain how AlphaFold achieves unprecedented accuracy in protein structure determination, showcase how molecular scientists can leverage it in their research, and present examples of researchers that are extending AlphaFold to new and exciting applications.