Birkir Þór Bragason
Researcher at the Institute for Experimental Pathology, University of Iceland, Keldur
E-mail: birkirbr (at) hi.is
Phone: +354 585 5100
1997 BSc in Biology from the University of Iceland
2006 PhD in Biomedicine from the University of Iceland
2006-present Research at the Institute for Experimental Pathology at Keldur
Research and current projects:
- Hereditary Cystatin C Amyloid Angiopathy (HCCAA) is a rare genetic disease in Icelandic families caused by a mutation in the cystatin C gene, CST3. Mutant cystatin C forms amyloid which is deposited in cerebral arteries resulting in fatal haemorrhagic strokes in young adults. The aim of the research is to clarify the aetiology of HCCAA pathology. The problem is being approached from several angles. Primary dermal fibroblasts from mutation carriers have been used to study the transcriptome (expression microarray) and proteome (iTRAQ) of the cells in comparison to controls. Alongside this, the pathology of the disease is being studied by immunohistochemistry. The HCCAA project is in collaboration with Ástríður Pálsdóttir.
- The acute phase response of cod (Gadus morhua L.) with an emphasis on gene expression changes. This research is in collaboration with Sigríður Guðmundsdóttir.