BMC Seminar Thursday 27th of January at 12:00 on Zoom: https://eu01web.zoom.us/j/66910511982
By combining high spatial and temporal resolution imaging with real-time reporters and light-mediated perturbations we found that microglia use microtubule-dependent extensions to capture dying neurons one after the other. This sequential uptake strongly correlates with the movement of the microglial centrosome. Indeed, translocation of this organelle into a microglial cellular extension coincides with phagocytic cup formation and subsequent neuronal removal at the tip of the extension. Interestingly, depolymerisation of microtubules, using a photo-activatable agent, showed that microglia in vivo are robust and highly plastic as they are able to switch to an alternative but equally controlled mode of phagocytosis characterised by directed migration towards dying neurons.
Short bio: Katrin was born in Reykjavik, Iceland. She obtained both her Bachelor’s degree in Biochemistry and Molecular Biology and Master’s degrees Biomedicine, at the University of Iceland. Her Bachelor’s thesis she did at the Steingrimsson’s lab, Biomedical Center, where she investigated the different 5’Ends of TFEB, a transcription factor important for lysosomal biogenesis and autophagy. Following her Bachelor’s degree she did an internship in the same lab, where she studied the transcriptional regulation of different subunits of the v-ATPase in melanoma cells. In 2014 she started her Master’s thesis in the Steingrimsson's lab, where she investigated the role of MITF in regulating starvation-induced autophagy in melanoma. During this time she visited the lab of Prof. Anne Simonsen at the University of Oslo, for 2 months, to get training in several autophagy-related research techniques. In fall 2016, she started her PhD at EMBL (Heidelberg, Germany) in Francesca Peri’s Group, where she studies the complex interplay between intracellular processing and microglia responses to neuronal cell death and injuries. In spring 2018 she moved with Francesca to the University of Zürich – IMLS (Switzerland), to continue her project.
Recently she has developed an interest in the environmental impact research has. In 2020 she joined the Faculty of Science Sustainability committee and established a Greenlab working group to address these problems and compe up with solutions on how to improve our environmental footprint in the lab