Thursday, October 25, 2018 -
12:00 to 13:00
BMC Seminar Thursday, October 25th at 12:00 in room 343 Læknagarður
Speaker: Dr. Valborg Guðmundsdóttir, post doctoral research fellow at the Icelandic Heart Assosiation, Faculty of Medicine, University of Iceland.
Title: Serum proteomics reveals biomarkers for incident type 2 diabetes
Abstract: The prevalence of type 2 diabetes mellitus (T2DM) is expected to increase rapidly in the next decades, posing a major challenge to societies worldwide. The emerging era of precision medicine calls for the discovery of biomarkers of clinical value for prediction of disease onset, where causal biomarkers can furthermore provide actionable targets. We applied a data-driven proteomics approach measuring serum levels of 4137 proteins in 5457 Icelanders to discover novel biomarkers for incident T2DM and further describe the serum protein profile of prevalent T2DM. In ongoing work, we have identified 537 serum proteins associated with incident or prevalent T2DM and, through LASSO penalized logistic regression analysis combined with bootstrap resampling, prioritized a panel of 20 protein biomarkers that significantly improves the prediction of incident T2DM over traditional risk factors. Finally, a Mendelian randomization analysis provides additional support for a causal role of 37 proteins in the development of T2DM, which could be of particular interest as novel therapeutic targets.