BMC Seminar Tuesday, June 5th at 12:00 in room 343 Læknagarður
Title: The role of MITF as determined using inducible mutations in mice.
Abstract: Our most visible phenotypes, skin, hair and eye color, are determined by the neural crest-derived melanocytes. These cells originate as precursor cells which then proliferate and migrate to their destination in skin, hair follicle and other tissues. These are also the cells that form melanomas. The MITF transcription factor is a key determinant of melanocyte development and function and is also critical for melanoma formation. In this talk I will discuss melanocyte development and the role of MITF. I will also present our latest work on the generation of an inducible mutation in MITF and how we can use it to proble the role of MITF in melanocytes and melanoma.