Title: The role of MITF in the response to DNA double strand breaks.
Abstract: The basis of a normal cell function is the integrity of the genome. When genome instability builds up it can cause uncontrolled cell proliferation that can develop into malignancies. Cells have developed a DNA damage response to sense lesions and repair them. DNA double strand breaks are considered the most cytotoxic of the DNA lesions. Many proteins play a part in the double strand breaks response and mutations in these proteins cause a predisposition of developing cancer. It has been shown that MITF, a well-established transcription factor of melanocytes, interacts with key factors of the DNA damage response. Here we show that MITF has a potential role in the double strand break response.
Síða uppfærð / breytt 10. February 2017. Númer síðu: 1311