Join BMC

Interested in joining the BMC?

 
With its recognized and engaged faculty, BMC offers excellent opportunities for masters students, PhD fellows and postdoctoral fellows to participate in cutting-edge research. 

Masters and PhD Projects

PhD and postdoctoral fellows

Group leaders at the BMC are always looking for highly motivated PhD fellows and postdocs. If there are currently no open calls posted on our website, excellent PhDs and postdocs are encouraged to apply to one of our groups for fellowships at any time. The chances for a position at BMC are increased significantly if you contact us well ahead of time. Please contact the Group Leader you wish to work with directly and please enclose the following materials:

1. Cover Letter/letter of interest
2. CV
3. Three (3) letters of reference 

Send email to skb@hi.is.

Work environment at BMC

BMC is a dynamic and international research centre. We offer good working conditions with excellent possibilities in an open, collaborative atmosphere. We offer state-of-the-art research facilities in modern laboratories. The research groups at BMC collaborate closely and all our young scientists (masters students, PhD fellows and postdocs) actively participate in all our activities.

1. Postdoctoral position

A post-doctoral position is available with Dr. Karl Karlsson at Reykjavik Unversity. The project revolves on the generation of novel models of ALS in zebrafish using CRISPR-Cas9 technology, high-througput screening and behavioral analysis.

Profile: The candiate should have a strong background in molecular biology or genetics, independent and driven. Previous experience with working with zebrafish is not a necessity.

We offer: Competitive salaries and exciting work environment in Reykjavik, Iceland.
Financing:
The project is funded by the Icelandic Centre for Research Technology Development grant and via collaboration with 3Z (www.3z.is)

Contact: Dr. Karl Ægir Karlsson Professor Biomedical Engineering School of Science and Engineering Reykjavik University Menntavegur 1, 101, Reykjavik, Iceland Tel: +(354) 599 6467 Cell: +(354) 825 6467 E-mail: karlsson@ru.is Web: www.karlsstofa.is / www.3z.is

2.Postdoctoral position in evolutionary genomics at the Institute of Life- and Environmental Sciences, University of Iceland

A postdoctoral position in population and evolutionary genomics is available in the research group of Einar Arnason at the Institute of Life- and Environmental Sciences (ILES) at University of Iceland.  We are looking for a highly motivated individual with strong computational skills, extensive experience working in the Linux environment, and strong interest in evolutionary and population genomics, to analyze and interpret extensive and unique whole-genome sequence data sampled from various gadid populations.

Field of work

Project title and description

Population genomics of highly fecund codfish

Our research focus is on understanding evolutionary processes in highly fecund organisms. We use highly fecund gadids as study organisms.  With a recently awarded Icelandic Research Fund Grant of Excellence (id 185151-051)  we will obtain unparalleled amount of whole-genome sequence data from various gadid populations.  Whole-genome sequence data holds huge promise in furthering our understanding of the mechanisms of selection, speciation and adaptation in natural populations.  The  grant of excellence project  is concerned with, among other things, understanding the mode of reproduction of gadids, mechanism of speciation, inferring the phylogeny of gadids, and identifying genetic units which may be under strong selection.  This collaborative project is joint with Katrin Halldorsdottir at ILES, Alison Etheridge at the Department of Statistics in University of Oxford, and Wolfgang Stephan and Bjarki Eldon at the Leibniz Institute for Evolution and Biodiversity Science in Berlin.  Among our collaborators are Montgomery Slatkin and Rasmus Nielsen at University of Berkeley in California, Fernando Racimo at Copenhagen University, and Tim Sackton which is Director of Bioinformatics at Harvard University.  This is a highly interdisciplinary project combining latest molecular technology, and advanced statistical and bioinformatic analysis.  We will maintain good communication  and collaboration between all participants.  The position therefore comes with possibilities to visit participating labs and groups in Berlin, Berkeley, and Cambridge (MA).  We would expect the postdoc to (i) work on ideas already developed in the project, and (ii) develop new ideas and new methods to analyze and understand the data.

Qualification requirements

  • PhD in computational biology, evolutionary or population genetics, or related fields;
  • demonstrated research ability in the form of publications and presentations;
  • ability to work both independently and within a team;
  • proficiency in written and spoken English
  • Strong experience working in the UNIX/Linux environment.
  • Strong interest in evolutionary and population genomics is an asset.
  • Experience in analyzing whole-genome sequences is an asset.
  • Programming experience in e.g. Python, R, Perl, C, C++, also is an asset.

How to apply

Please include in your application:

i) 1-3 page motivation letter, which should state your interest in the project, what makes you  qualified for the position,  and your ideas for how to move the project forward;ii) CV and publication list,

iii) transcripts from B.Sc. and M.Sc. studies, and a list of courses during postgraduate studies,

iv) contact information for 2-3 letters of

The successful applicant could anticipate to start work as early as July/August2018, with funding guaranteed for three years. This is a full-time position. 

Salary will be according to the current collective wage and salary agreement between the Union of University Teachers and the Minister of Finance.

All applications will be answered and applicants will be notified of the employment decision when a decision has been made. Applications will be valid for six months from the end of the application deadline.

Some relevant articles

Einar Árnason and Katrín Halldórsdóttir. 2015.  Nucleotide variation and balancing selection at the Ckma gene in Atlantic cod: analysis with multiple merger coalescent models. PeerJ e786. doi:10.7717/peerj.786

Bjarki Eldon and John Wakeley 2006. Coalescent processes when the distribution of offspring number among individuals is highly skewed. Genetics 172:2621-2633. doi:10.1534/genetics.105.052175

Bjarki  Eldon,  Matthias Birkner,  Jochen Blath  and Fabian Freund 2015. Can the site-frequency spectrum distinguish exponential population growth from multiple-merger coalescents? Genetics  199: 841-856. doi:10.1534/genetics.114.173807

Katrín Halldórsdóttir and  Einar Árnason 2015. Whole-genome sequencing uncovers cryptic and hybrid species among Atlantic and Pacific cod-fish. BioRxiv,  doi:10.1101/034926.

Fernando Racimo 2015. Testing for ancient selection using cross-population allele frequency differentiation. Genetics 202:733-750.

Joshua G. Schraiber and Steven N. Evans and Montgomery Slatkin 2016. Bayesian inference of natural selection from allele frequency time series. Genetics 203: 493-511. doi:10.1534/genetics.116.187278

Appointments to positions at the University of Iceland are made in consideration of the Equal Rights Policy of the University of Iceland.

The University of Iceland has a special Language Policy.

The School of Engineering and Natural Sciences employs ca. 360 people in academic positions. The School offers an international working environment, with the number of international employees and students increasing each year. Currently about quarter of all employees and graduate students are international. There are around 2900 students at the School, divided into six faculties, including approximately 350 MS students and 150 doctoral students. Research institutes at the School are the Science Institute that divides into the Institute of Earth Sciences and Institute of Physical Sciences, Institute of Life and Environmental Sciences, Engineering Research Institute and the Institute for Sustainability Studies which is an interdisciplinary institute and belongs to the five schools of the University of Iceland.

The University of Iceland is the largest teaching, research and science institute in Iceland and is ranked among the top 250 universities in the world by Times Higher Education.

More information about the University of Iceland can be found at the University of Iceland website, Relocation Service.

Further information

For further information, please contact Einar Arnason (einararn@hi.is)

Deadline

The application deadline is through the 16th July, 2018
 

3. PhD student position at the Institute of Life- and Environmental Sciences

The evolutionary and population genomics group of Einar Arnason at the Institute of Life- and Environmental Sciences (ILES) at University of Iceland invites applications for a PhD position in evolutionary genomics for the research topic: Analysis of time-series of whole-genome data from highly fecund gadids.

Field of work

Our research focus is on understanding evolutionary processes in highly fecund organisms. We use highly fecund gadids as study organisms.  With a recently awarded Icelandic Research Fund Grant of Excellence we will obtain unparalleled amount of whole-genome sequence data from various gadid populations.  Whole-genome sequence data holds huge promise in furthering our understanding of the mechanisms of selection, speciation and adaptation in natural populations.  This collaborative project is joint with Katrin Halldorsdottir at ILES, Alison Etheridge at the Department of Statistics in University of Oxford, and Wolfgang Stephan and Bjarki Eldon at the Leibniz Institute for Evolution and Biodiversity Science in Berlin.  Among our collaborators are Montgomery Slatkin and Rasmus Nielsen at University of Berkeley in California, Fernando Racimo Centre for GeoGenetics Copenhagen University and Tim Sackton  Director of Bioinformatics at Harvard University.

The student will be based at University of Iceland and  work under the supervision of  Einar Arnason, Katrin Halldórsdóttir, and  Bjarki Eldon in Berlin.  This is a highly interdisciplinary project combining latest molecular technology, and advanced statistical and bioinformatic analysis.  We will maintain good communication between all participants.  The position therefore comes with possibilities to visit participating labs and groups in Berlin, Berkeley, Copenhagen, Oxford, and Cambridge (MA).

Analysis of time-series of samples using whole-genome sequencing promises to be a powerful way of understanding evolutionary history, in particular, for detecting selection. The PhD project is about the time-series part of the overall project.

We are looking for a highly motivated individual with a strong interest in evolutionary and population genomics.  The University of Iceland expects PhD candidates to complete their studies and write and defend a dissertation within a time period of 3 years after a master’s degree according to the Bologna process.

Qualification requirements

- M.Sc. (or equivalent) in biology, statistics, mathematics, or  computer science;

- experience in some kind of data analysis;

- the ability to work both independently and in a team;

- proficiency in written and spoken English

- experience in analysing genomic data is an asset;

- strong interest in evolutionary biology and genomics is an asset;

- experience in working with UNIX/Linux is an asset

How to apply

Please include the following in the application:

i) 1-2 page motivation letter, which should state interest in the project, expectations for your Ph.D. studies and what makes you qualified for the position,

ii) CV and publication list (if any),

iii) transcripts from B.Sc. and M.Sc. studies, and a list of courses during postgraduate studies,

iv) contact information for 2 letters of reference

The successful applicant could anticipate to start work as early as July 2018, or later upon agreement, with funding guaranteed for three years.

Salary will be according to the current collective wage and salary agreement between the Union of University Teachers and the Minister of Finance.

All applications will be answered and applicants will be notified of the employment decision when a decision has been made. Applications will be valid for six months from the end of the application deadline.

Some relevant publications

Einar Árnason and Katrín Halldórsdóttir. 2015.  Nucleotide variation and balancing selection at the Ckma gene in Atlantic cod: analysis with multiple merger coalescent models. PeerJ e786. doi:10.7717/peerj.786

Bjarki Eldon and John Wakeley 2006. Coalescent processes when the distribution of offspring number among individuals is highly skewed. Genetics 172:2621-2633. doi:10.1534/genetics.105.052175

Bjarki  Eldon,  Matthias Birkner,  Jochen Blath  and Fabian Freund 2015. Can the site-frequency spectrum distinguish exponential population growth from multiple-merger coalescents? Genetics  199: 841-856. doi:10.1534/genetics.114.173807

Fernando Racimo 2015. Testing for ancient selection using cross-population allele frequency differentiation. Genetics 202:733-750.

Joshua G. Schraiber and Steven N. Evans and Montgomery Slatkin 2016. Bayesian inference of natural selection from allele frequency time series. Genetics 203: 493-511. doi:10.1534/genetics.116.187278

Appointments to positions at the University of Iceland are made in consideration of the Equal Rights Policy of the University of Iceland.

The University of Iceland has a special Language Policy.

The School of Engineering and Natural Sciences employs ca. 360 people in academic positions. The School offers an international working environment, with the number of international employees and students increasing each year. Currently about quarter of all employees and graduate students are international. There are around 2900 students at the School, divided into six faculties, including approximately 350 MS students and 150 doctoral students. Research institutes at the School are the Science Institute that divides into the Institute of Earth Sciences and Institute of Physical Sciences, Institute of Life and Environmental Sciences, Engineering Research Institute and the Institute for Sustainability Studies which is an interdisciplinary institute and belongs to the five schools of the University of Iceland.

The University of Iceland is the largest teaching, research and science institute in Iceland and is ranked among the top 250 universities in the world by Times Higher Education.

More information about the University of Iceland can be found at the University of Iceland website, Relocation Service.

Further information

For further information, please contact Einar Arnason (einararn@hi.is)

Deadline

The application deadline is through the 16th July, 2018

4. Mastersnemi í krabbameinsrannsóknum við Lífvísindasetur Háskóla Íslands

Óskað er eftir mastersnema til að vinna að rannsóknum á tengslum DNA viðgerðar og krabbameins.  Nemandinn mun vinna undir leiðsögn Stefán Sigurðssonar dósents og Þorkels Guðjónssonar nýdoktors við lífefnafræðisvið Heilbrigðisvísindardeildar.

Leitað er eftir áhugasömum nemanda með góða grunnþekkingu í sameinda– og frumulíffræði. Æskilegt er að umsækjandi hafi góð tök á ensku og góða samskiptahæfni.

Um verkefnið: Krabbamein er ein helsta dánarorsök í hinum vestræna heimi. Eitt af megin einkennum krabbameinsfrumna er óstöðugt erfðamengi, sem einkennist af hárri tíðni stökkbreytinga. Þessi óstöðugleiki er talinn stafa af uppsöfnun DNA skemmda sem fruman nær ekki að meðhöndla. Ómeðhöndlaðar skemmdir geta leitt til stökkbreytinga sem ýta undir stjórnlausan frumuvöxt. Að meðaltaði er áætlað að hver fruma innan mannslíkaman verði fyrir u.þ.b. 60.000 mismunandi DNA skemmdum á dag. Til að bregðast við þessu stöðuga áreiti býr fruman yfir mjög öflugu eftirlitskerfi sem skynjar og gerir við DNA skemmdir, og lágmarkar þar með áhættuna á myndun krabbameins.  Einstaklingar með stökkbreytingar í lykilgenum þessa kerfis, t.d. BRCA1 og BRCA2, eru í aukinni hættu á að fá krabbamein.

Markmið okkar rannsókna er að finna gen með áður óþekkt tengsl við eftirlitskerfi frumunar gegn DNA skemmdum, og kortlegga hugsanlega virkni þeirra í DNA viðgerð. Aukin þekking á starfsemi þessa kerfis er grundvöllur þess að skilja lífræðilega orsök krabbameina og gæti haft mikla þýðing fyrir krabbameinsmeðferð.

Áhugasömum nemendum er vinsamlegast bent á að hafa sambandi við Stefán Sigurðsson (stefsi@hi.is) eða Þorkel Guðjónsson (thgud@hi.is)

5. Advertisment for a master´s research project at the LSH Immunology department

Title: Study and EBV-transformation of B cells from individuals with selective IgA deficiency

Supervisors: Björn Rúnar Lúðvíksson (bjornlud@landspitali.is), Helga Kristín Einarsdóttir (helgake@landspitali.is) and Andri Leó Lemarquis (andrileo@landspitali.is)

Brief summary of project

Individuals are diagnosed as selective IgA deficient (sIgAD) when their IgA serum concentration is below 0,7 mg/dL while IgG and IgM are within the normal range.

Over the past few years thorough new research has helped to elucidate the causes, heredity and consequences of selective IgA deficiency.

After studying the phenotype, function and gene expression of B cells in IgA deficient individuals, our group has demonstrated a defect in the maturation and differentiation of B cells, TLR9 activation and the expression of certain genes. Although of very low numbers, it is possible to find IgA positive B cells in the blood from IgA deficient individuals. It would be interesting to study them further in order to elucidate which processes might be defective in the B cell maturation of those individuals. The goal of this project is then to set up a protocol for immortalize IgA positive B cells with EBV virus in order to create an IgA secreting B cell line. These cell lines will then be used as material for further study, e.g. by flow cytometry, electron microscopy and confocal imaging microscopy.

Our Research Question is:

Is it feasible to generate B cell lines from IgA deficient individuals, and if so, what is their phenotype?

Methods and scope

Student will be trained in methods for flow cytometry, EBV transfection of PBMCs, cell culturing as well as confocal and electron microscope imaging.

Location of facilities

Landspítali University Hospital, Immunology department

Approvals

This research has been approved by the following committees

Science research ethics committee VSN-13-109-S1

Data protection authority: 2008110777

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