Interested in joining the BMC?
With its recognized and engaged faculty, BMC offers excellent opportunities for masters students, PhD fellows and postdoctoral fellows to participate in cutting-edge research.
Masters and PhD Projects
PhD and postdoctoral fellows
Group leaders at the BMC are always looking for highly motivated PhD fellows and postdocs. If there are currently no open calls posted on our website, excellent PhDs and postdocs are encouraged to apply to one of our groups for fellowships at any time. The chances for a position at BMC are increased significantly if you contact us well ahead of time. Please contact the Group Leader you wish to work with directly and please enclose the following materials:
1. Cover Letter/letter of interest
3. Three (3) letters of reference
Send email to firstname.lastname@example.org.
Work environment at BMC
BMC is a dynamic and international research centre. We offer good working conditions with excellent possibilities in an open, collaborative atmosphere. We offer state-of-the-art research facilities in modern laboratories. The research groups at BMC collaborate closely and all our young scientists (masters students, PhD fellows and postdocs) actively participate in all our activities.
1. Post-doctoral researcher in Bioinformatics Research and service at the School of Engineering and Natural Sciences
We are seeking for a Post doctoral researcher in bioinformatics to work on research and to build up bioinformatic services at the University of Iceland. The university has established Mimir, a computer cluster for bioinformatic analyses. The researcher will have dual responsibilities, one as a bioinformatics manager working with different research groups, many of which take part in the Biomedical center, University of Iceland (http://lifvisindi.hi.is/) and the other as a researcher working with the Melsted bioinformatics group (https://melstedlab.github.io).
Field of work
The managerial duties are, installing and maintaining selected bioinformatic programs and libraries, establish analysis workflows, assist groups with specific projects and analyses, train graduate students and other researchers.
The research project with the Melsted group will focus on development of algorithms for high throughput sequencing and programs for analyses of DNA/RNA assembly or RNA quantification.
The candidate will have an opportunity to take part in ongoing research projects, earn co-authorship on scientific manuscripts, and perform independent research.
- Doctoral degree in bioinformatics, computational biology, biostatistics, or equivalent.
- Extensive experience working in bioinformatics, computational biology, biostatistics, or equivalent is required.
- Practical experience with linux and bioinformatics, for example installing programs, scripts, libraries and handling updates, programming and scripting in Python, R/Bioconductor and bash and run next-generation genome data analyses programs is essential.
- Direct experience and interest in developing bioinformatic software and develop accessible tools and workflows for the scientific community is desired.
How to apply
The position is available for two years with a possibility of an extension should the project be continued.
The applicant is expected to start the position as soon as possible.
Please include the following with the application:
- Description of how the applicant meets the requirements, interests in the project and how they can contribute to the project (max 2 pages).
- Certificates of education (BSc, MSc, PhD) and distribution of grades.
- The name, telephone number and e-mail address of two referrals (with a statement of their connection to the applicant).
- Overview of publications if applicable.
- Applicants are also invited to send PDF of MS and/or PhD thesis (in any language) and any other relevant publications if available (max 5 documents).
Salary will be according to the current collective wage and salary agreement between the Union of University Teachers and the Minister of Finance.
All applicants will receive a reply and they will be informed as to the selection of a successful applicant when the decision has been made. Applications may be valid for up to 6 months after the closing of the application deadline.
Appointments to positions at the University of Iceland are made in consideration of the Equal Rights Policy of the University of Iceland.
The University of Iceland has a special Language Policy.
The School of Engineering and Natural Sciences employs ca. 360 people in academic positions. The School offers an international working environment, with the number of international employees and students increasing each year. Currently about quarter of all employees and graduate students are international. There are around 2900 students at the School, divided into six faculties, including approximately 350 MS students and 150 doctoral students. Research institutes at the School are the Science Institute that divides into the Institute of Earth Sciences and Institute of Physical Sciences, Institute of Life and Environmental Sciences, Engineering Research Institute and the Institute for Sustainability Studies which is an interdisciplinary institute and belongs to the five schools of the University of Iceland.
The University of Iceland is the largest teaching, research and science institute in Iceland and is ranked among the top 250 universities in the world by Times Higher Education.
More information about the University of Iceland can be found at the Relocation Service here.
2. Mastersnemi í krabbameinsrannsóknum við Lífvísindasetur Háskóla Íslands
Óskað er eftir mastersnema til að vinna að rannsóknum á tengslum DNA viðgerðar og krabbameins. Nemandinn mun vinna undir leiðsögn Stefán Sigurðssonar dósents og Þorkels Guðjónssonar nýdoktors við lífefnafræðisvið Heilbrigðisvísindardeildar.
Leitað er eftir áhugasömum nemanda með góða grunnþekkingu í sameinda– og frumulíffræði. Æskilegt er að umsækjandi hafi góð tök á ensku og góða samskiptahæfni.
Um verkefnið: Krabbamein er ein helsta dánarorsök í hinum vestræna heimi. Eitt af megin einkennum krabbameinsfrumna er óstöðugt erfðamengi, sem einkennist af hárri tíðni stökkbreytinga. Þessi óstöðugleiki er talinn stafa af uppsöfnun DNA skemmda sem fruman nær ekki að meðhöndla. Ómeðhöndlaðar skemmdir geta leitt til stökkbreytinga sem ýta undir stjórnlausan frumuvöxt. Að meðaltaði er áætlað að hver fruma innan mannslíkaman verði fyrir u.þ.b. 60.000 mismunandi DNA skemmdum á dag. Til að bregðast við þessu stöðuga áreiti býr fruman yfir mjög öflugu eftirlitskerfi sem skynjar og gerir við DNA skemmdir, og lágmarkar þar með áhættuna á myndun krabbameins. Einstaklingar með stökkbreytingar í lykilgenum þessa kerfis, t.d. BRCA1 og BRCA2, eru í aukinni hættu á að fá krabbamein.
Markmið okkar rannsókna er að finna gen með áður óþekkt tengsl við eftirlitskerfi frumunar gegn DNA skemmdum, og kortlegga hugsanlega virkni þeirra í DNA viðgerð. Aukin þekking á starfsemi þessa kerfis er grundvöllur þess að skilja lífræðilega orsök krabbameina og gæti haft mikla þýðing fyrir krabbameinsmeðferð.
3. Advertisment for a master´s research project at the LSH Immunology department
Title: Study and EBV-transformation of B cells from individuals with selective IgA deficiency
Brief summary of project
Individuals are diagnosed as selective IgA deficient (sIgAD) when their IgA serum concentration is below 0,7 mg/dL while IgG and IgM are within the normal range.
Over the past few years thorough new research has helped to elucidate the causes, heredity and consequences of selective IgA deficiency.
After studying the phenotype, function and gene expression of B cells in IgA deficient individuals, our group has demonstrated a defect in the maturation and differentiation of B cells, TLR9 activation and the expression of certain genes. Although of very low numbers, it is possible to find IgA positive B cells in the blood from IgA deficient individuals. It would be interesting to study them further in order to elucidate which processes might be defective in the B cell maturation of those individuals. The goal of this project is then to set up a protocol for immortalize IgA positive B cells with EBV virus in order to create an IgA secreting B cell line. These cell lines will then be used as material for further study, e.g. by flow cytometry, electron microscopy and confocal imaging microscopy.
Our Research Question is:
Is it feasible to generate B cell lines from IgA deficient individuals, and if so, what is their phenotype?
Methods and scope
Student will be trained in methods for flow cytometry, EBV transfection of PBMCs, cell culturing as well as confocal and electron microscope imaging.
Location of facilities
Landspítali University Hospital, Immunology department
This research has been approved by the following committees
Science research ethics committee VSN-13-109-S1
Data protection authority: 2008110777