Join BMC

Interested in joining the BMC?

 
With its recognized and engaged faculty, BMC offers excellent opportunities for masters students, PhD fellows and postdoctoral fellows to participate in cutting-edge research. 

Masters and PhD Projects

PhD and postdoctoral fellows

Group leaders at the BMC are always looking for highly motivated PhD fellows and postdocs. If there are currently no open calls posted on our website, excellent PhDs and postdocs are encouraged to apply to one of our groups for fellowships at any time. The chances for a position at BMC are increased significantly if you contact us well ahead of time. Please contact the Group Leader you wish to work with directly and please enclose the following materials:

1. Cover Letter/letter of interest
2. CV
3. Three (3) letters of reference 

Send email to skb@hi.is.

Work environment at BMC

BMC is a dynamic and international research centre. We offer good working conditions with excellent possibilities in an open, collaborative atmosphere. We offer state-of-the-art research facilities in modern laboratories. The research groups at BMC collaborate closely and all our young scientists (masters students, PhD fellows and postdocs) actively participate in all our activities.

1. PhD position in Immunology at the Biomedical Center (BMC), University of Iceland

A PhD student position is available at the Faculty of Medicine, University of Iceland to study resolution of inflammation and especially the role of neutrophils in resolution of inflammation.

Resolution of inflammation is important as chronic inflammation is a causative factor in many diseases. We have shown that dietary omega-3 PUFA may enhance resolution of inflammation and also that NK cells play a crucial role in antigen-induced inflammation. The PhD project will focus on the potential role of neutrophils in resolution of inflammation.

Professors Jona Freysdottir and Ingibjorg Hardardottir will supervise the student. Their laboratories, both belonging to BMC, are situated at the Department of Immunology at Landspitali-The National University Hospital of Iceland and the Biochemistry and Molecular Biology facility, Faculty of Medicine, University of Iceland. The project is performed in collaboration with scientists at Leiden University in the Netherlands and the Semmelweis University in Hungary.

The BMC is an official collaboration between research groups working in Biomedical Molecular Life Sciences within the University, the University Hospital, Reykjavik University and other institutions in Iceland.  It includes over 70 Principle Investigators and over one hundred graduate students and postdocs. For further information on the BMC see: http://lifvisindi.hi.is/. 

Interested applicants are invited to send a copy of their CV, letter of recommendation, contact information for 2 references (address, phone number, e-mail), and a brief statement of career goals to Jona Freysdottir (jonaf@landspitali.is) or Ingibjorg Hardardottir (ih@hi.is).

2. PhD studentships available in transcriptional regulation at the Biomedical Center

We are looking for two highly qualified and motivated researchers for Ph.D. positions focusing on transcription regulation during melanocyte proliferation and in mouse embryonic stem cells, at the University of Iceland, Reykjavík.

The projects are supported by the University of Iceland Doctoral Fund for three years.

The studentships are at the Biomedical Center (www.lifvisindi.hi.is) and are associated with the Faculty of Medicine and the Graduate Program in Molecular Life Sciences.  The graduate program is a joint program between research groups at the University of Iceland and research organizations associated with the University. The main objective of GPMLS is to create a dynamic interdisciplinary educational program and to advance research and education in the field of molecular life sciences. The program offers research and education opportunities in a stimulating environment for students working towards MSc or PhD.

Field of work

PhD Position (Transcription regulation during melanocyte proliferation)

The student will determine the role of the melanocyte specific transcription factor MITF in regulating cell proliferation. The approach will use both mouse and cell models to characterize how MITF mediates effects on proliferation. In addition the project will depend on RNA-seq and ChIP-seq data and will use traditional methods of molecular biology, including transcription activation assays. Eiríkur Steingrímsson, professor in the Faculty of Medicine will be the supervisor (http://lifvisindi.hi.is/staff/eirikur-steingrimsson).

PhD Position (Mouse Embryonic Stem Cells)

The student will investigate transcriptional mechanisms in mouse embryonic stem cell fate commitment, with the aim of generating a better understanding of molecular mechanisms of early embryonic development.  The approach will focus on genome wide assays such as chromatin immunoprecipitation and gene expression analysis coupled to high throughput sequencing in addition to molecular biology, biochemistry, cell biology techniques as well as CRISPR-Cas9 based genome editing techniques. Erna Magnúsdóttir, associate professor at the Faculty of medicine, will be the projects supervisor.

[http://magnuslab.is/].

Qualification requirements

  • We are looking for excellent students with a MSc degree in cell biology, biochemistry or a related discipline.
  • Good experience working on research in a laboratory setting on molecular biology and cell biology assays.
  • Experience and skills in mammalian cell culture are essential
  • Good Computer skills.
  • Fluency in both written and spoken English is essential.
  • The applicants need to be able to work independently and have strong communication and interpersonal skills.
  • The applicants must meet the requirements needed to enrol into the School of Health Sciences Ph.D. program.

How to apply

Please include the following with the application:

  • Description of how the applicant meets the requirements, his/her interests in the project, one of them or both, and how he/she can contribute to the project (max 2 pages).
  • CV.
  • Certificates of education (BS and MSc degree) and distribution of grades.
  • The name, telephone number and e-mail address of two referrals (their relationship to the applicant).
  • Overview of publications.
  • Applicants are also invited to send PDF of MS thesis (in any language) and any other relevant publications if available (max 5 documents).

The applicant is expected to start in September 2018.

The salary for the position will be in accordance with the current collective wage and salary agreement between the trade union and the Minister of Finance.

Appointments to positions at the University of Iceland are made in consideration of the Equal Rights Policy of the University of Iceland.

 

The School of Health Sciences at the University of Iceland is a national leader in the field of health care and has played a key role in the build-up of the Icelandic health care system. The school is comprised of six faculties: Faculty of Nursing; Faculty of Pharmaceutical Sciences; Faculty of Medicine; Faculty of Food Science and Nutrition; Faculty of Psychology and Faculty of Odontology.

Further information

For more information, please contact Eiríkur Steingrímsson (eirikurs@hi.is) or Erna Magnúsdóttir (erna@hi.is).

Deadline

The application deadline is through the 22nd May, 2018

 

3. Mastersnemi í krabbameinsrannsóknum við Lífvísindasetur Háskóla Íslands

Óskað er eftir mastersnema til að vinna að rannsóknum á tengslum DNA viðgerðar og krabbameins.  Nemandinn mun vinna undir leiðsögn Stefán Sigurðssonar dósents og Þorkels Guðjónssonar nýdoktors við lífefnafræðisvið Heilbrigðisvísindardeildar.

Leitað er eftir áhugasömum nemanda með góða grunnþekkingu í sameinda– og frumulíffræði. Æskilegt er að umsækjandi hafi góð tök á ensku og góða samskiptahæfni.

Um verkefnið: Krabbamein er ein helsta dánarorsök í hinum vestræna heimi. Eitt af megin einkennum krabbameinsfrumna er óstöðugt erfðamengi, sem einkennist af hárri tíðni stökkbreytinga. Þessi óstöðugleiki er talinn stafa af uppsöfnun DNA skemmda sem fruman nær ekki að meðhöndla. Ómeðhöndlaðar skemmdir geta leitt til stökkbreytinga sem ýta undir stjórnlausan frumuvöxt. Að meðaltaði er áætlað að hver fruma innan mannslíkaman verði fyrir u.þ.b. 60.000 mismunandi DNA skemmdum á dag. Til að bregðast við þessu stöðuga áreiti býr fruman yfir mjög öflugu eftirlitskerfi sem skynjar og gerir við DNA skemmdir, og lágmarkar þar með áhættuna á myndun krabbameins.  Einstaklingar með stökkbreytingar í lykilgenum þessa kerfis, t.d. BRCA1 og BRCA2, eru í aukinni hættu á að fá krabbamein.

Markmið okkar rannsókna er að finna gen með áður óþekkt tengsl við eftirlitskerfi frumunar gegn DNA skemmdum, og kortlegga hugsanlega virkni þeirra í DNA viðgerð. Aukin þekking á starfsemi þessa kerfis er grundvöllur þess að skilja lífræðilega orsök krabbameina og gæti haft mikla þýðing fyrir krabbameinsmeðferð.

Áhugasömum nemendum er vinsamlegast bent á að hafa sambandi við Stefán Sigurðsson (stefsi@hi.is) eða Þorkel Guðjónsson (thgud@hi.is)

4. Advertisment for a master´s research project at the LSH Immunology department

Title: Study and EBV-transformation of B cells from individuals with selective IgA deficiency

Supervisors: Björn Rúnar Lúðvíksson (bjornlud@landspitali.is), Helga Kristín Einarsdóttir (helgake@landspitali.is) and Andri Leó Lemarquis (andrileo@landspitali.is)

Brief summary of project

Individuals are diagnosed as selective IgA deficient (sIgAD) when their IgA serum concentration is below 0,7 mg/dL while IgG and IgM are within the normal range.

Over the past few years thorough new research has helped to elucidate the causes, heredity and consequences of selective IgA deficiency.

After studying the phenotype, function and gene expression of B cells in IgA deficient individuals, our group has demonstrated a defect in the maturation and differentiation of B cells, TLR9 activation and the expression of certain genes. Although of very low numbers, it is possible to find IgA positive B cells in the blood from IgA deficient individuals. It would be interesting to study them further in order to elucidate which processes might be defective in the B cell maturation of those individuals. The goal of this project is then to set up a protocol for immortalize IgA positive B cells with EBV virus in order to create an IgA secreting B cell line. These cell lines will then be used as material for further study, e.g. by flow cytometry, electron microscopy and confocal imaging microscopy.

Our Research Question is:

Is it feasible to generate B cell lines from IgA deficient individuals, and if so, what is their phenotype?

Methods and scope

Student will be trained in methods for flow cytometry, EBV transfection of PBMCs, cell culturing as well as confocal and electron microscope imaging.

Location of facilities

Landspítali University Hospital, Immunology department

Approvals

This research has been approved by the following committees

Science research ethics committee VSN-13-109-S1

Data protection authority: 2008110777

Þú ert að nota: brimir.rhi.hi.is