Málstofa Lífvísindaseturs fimmtudaginn 11. desember kl. 16:00 í stofu 343, Læknagarði

Hefur curcumin eituráhrif á krabbameinsfrumur?

Asto Raasmaja prófessor í eiturefnafræði við Lyfjafræðideild Helskinkiháskóla í Finnlandi mun segja frá áhrifum curcumins á krabbameinsfrumur og notkun efnisins og annarra plöntuefna í lyfjaþróun.

Erindið verður flutt á ensku og er öllum opið.

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This week BMC Seminar Thursday, 11th December at Læknagarður, room 343 at 16:00

Speaker: Atso Raasmaja, Professor in Toxicology, Division of Pharamcology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Finland

Title: Cytotoxicity of natural phenolic compounds and plant extracts in cell cultures

Short abstract:

The health-promoting effects of natural phenolic compounds are attracting growing interest. We have studied different plant extracts e.g. basil, juniper, laurel and parsley and pure phenolic compounds of natural origin (e.g. curcumin and resveratrol), for their possible cytotoxic effects in vitro in human SH-SY5Y neuroblastoma cells, CV1-P fibroblast cells and some other cell lines. Cytotoxicity was examined by MTT and LDH assays, DNA fragmentation, Western blotting and other analysis. E.g., Juniper extract decreased the cell viability and increased the amount of p53 in SH-SY5Y cells at lower concentrations than did other plant extracts, and its effects on the amount of p53 in the cells were comparable to the treatment with 50 uM AraC as a reference compound. The actions of curcumin and resveratrol were dependent on the concentration and cell line. Curcumin decreased the cell viability and increased the amount of p53 in SH-SY5Y cells more effectively than in CV1-P cells. These results indicate a potential role of plant extracts and plant-derived compounds as health-promoting food constituents as well as candidates for drug development as suggested also in many other reports.