Málstofa Lífvísindaseturs verður haldin fimmtudaginn 28. ágúst kl. 12-13 í stofu 343 í Læknagarði
Dr. William Hanneman prófessor í eiturefnafræði, Center for Environmental Medicine, College of Veterinary Medicine and Biomedical Sciences við Colorado State háskólann í Fort Collins mun fyrst kynna stofnun sína, en svo halda erindið: Orsakakeðja hormónatruflunar af völdum atrazíns (e. Molecular Mechanisms of Endocrine Disruption: Focus on Atrazine).
Hann er hér á ferð ásamt eiginkonu sinni, en bæði eru þau prófessorar við Colorado State háskólann og vilja nýta ferðina til að kynna meistaranám í eiturefnafræðum við Colorado State háskólann og koma á samstarfi við Háskóla Íslands.
Klórtríazín efni eins og atrazín eru algengustu illgresiseyðar sem notaðir eru í Bandaríkjunum (30000 tonn/ár). Efnin valda margvíslegum neikvæðum áhrifum á æxlun í tilraunadýrum í gegnum sértæka truflun á undirstúku-heiladingul-kynkirtla tengingu. Lítið er sannað um áhrif á menn, en gögn benda til að efnin geti valdið neikvæðum áhrifum á frjósemi og meðgöngu. Rannsóknir hafa sýnt að þessi áhrif megi rekja til hindrunar á hækkun Lutenizing hormóns fyrir egglos og kynnt verður ný tillaga að orsakakeðju truflunar starfsemi frumna sem stýrast af gonadotrópíni.
Erindið verður á ensku.
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This week BMC seminar will be given by Dr. William H. Hanneman, Professor of Toxicology at Center for Environmental Medicine, College of Veterinary Medicine and Biomedical Sciences in Colorado State University will give a brief overview of the Center for Environmental Medicine, followed by a scientific talk: "Molecular Mechanisms of Endocrine Disruption: Focus on Atrazine".
Thursday 28th August at 12:00 in room 343 at Læknagarður
Overview: Chemicals that cause neurological deficits are a structurally diverse group and not well understood. Cellular toxicity can occur when electrophilic adduct formation disrupts protein structure and/or function, which secondarily causes damage to organelles, metabolic pathways, and/or physiological processes. Since many neurotoxicants are also electrophiles, our laboratory has hypothesized that the corresponding pathophysiological mechanisms of neuroendocrine disruption involve protein adduction and dysfunction.
Seminar Specifics: Chlorotriazine (Cl-TRI) compounds such as atrazine (ATRA) are the most commonly used herbicides in the United States, with more that 30,000 tons (60 million pounds) applied annually. Exposure to ATRA and other Cl-TRIs causes a spectrum of reproductive deficits in laboratory species that involve selective disruption of the hypothalamic-pituitary gonadal (HPG) axis. Data on the effects of ATRA in humans are scares but suggest that environmental exposures to ATRA may increase parental risk of infertility and adverse pregnancy outcomes. Our laboratory has traced the roots of this dysfunction to suppression of the pre-ovulatory surge of luteinizing hormone (LH) and propose a novel mechanism of cellular disruption in gonadotroph cells.
The Center for Environmental Medicine
Overview: The Toxicology program within the Center for Environmental Medicine, College of Veterinary Medicine has long held a National reputation for excellence in research. The Toxicology program was formerly designated as a Program of Research and Scholarly Excellence (PRSE) at CSU and holds a diverse portfolio of intramural and extramural programmatic grants. As the founding Director of the CEM he was charged by the Dean and Governor with the responsibility of building upon these successes in research to more broadly develop an International interdisciplinary research program in multiple fields relevant to the environmental health sciences. As such, we are actively developing international interdisciplinary teams of scientists capable of solving complex toxicological problems.