BMC Seminar Thursday, 2nd June at 12:00 Room 343 Læknagarður

Speaker: Eric J. Brown, Associate Investigator and Director of Education, Abramson Family Cancer Research Institute, Associate Professor, Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania

Title: Defining mechanisms of replication fork collapse to identify novel cancer therapies

Abstract: His laboratory studies the mechanisms that safeguard the genome during replication and investigates how defects in these processes impact tissue homoeostasis, cancer risk, and cancer treatment. Recently, our work in these areas have focused on three distinct levels: 1) the role of ATR in preventing replication fork collapse and genomic instability,  2) the genomic sites of replication fork collapse from ATR inhibition, and 3) the promise of ATR inhibitors as cancer treatments.